Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes.

• Main Authors: Geoffrey N Gobert (Author), Mai H Tran (Author), Luke Moertel (Author), Jason Mulvenna (Author), Malcolm K Jones (Author), Donald P McManus (Author), Alex Loukas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Schistosomes cause more mortality and morbidity than any other human helminth, but control primarily relies on a single drug that kills adult worms. The newly transformed schistosomulum stage is susceptible to the immune response and is a target for vaccine development and rational drug...