The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells

• Główni autorzy: Vida Vafaizadeh (Autor), Bernd Groner (Autor), Boris Brill (Autor), Natalia Delis (Autor), Richard Moriggl (Autor), Corina Borghouts (Autor), Christian Brendel (Autor), Axel Weber (Autor)
• Format: Książka
• Wydane: MDPI AG, 2013-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was initially observed in leukemias, but subsequently al...