Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.

• Main Authors: Frederick A Partridge (Author), Emma A Murphy (Author), Nicky J Willis (Author), Carole J R Bataille (Author), Ruth Forman (Author), Narinder Heyer-Chauhan (Author), Bruno Marinič (Author), Daniel J C Sowood (Author), Graham M Wynne (Author), Kathryn J Else (Author), Angela J Russell (Author), David B Sattelle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of those infected. Current drug treatment options are limited and lack efficacy against the worm, preventing an eradication programme. It is theref...