Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance

• Main Authors: Yue Wang (Author), Zihui Fang (Author), Mei Hong (Author), Da Yang (Author), Wen Xie (Author)
• Formato: Libro
• Publicado: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Drug metabolism is an orchestrated process in which drugs are metabolized and disposed through a series of specialized enzymes and transporters. Alterations in the expression and/or activity of these enzymes and transporters can affect the bioavailability (pharmacokinetics, or PK) and therapeutic ef...