Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment

• Main Authors: Se Ra Sung (Author), Seung Hun Song (Author), Kyung Min Kang (Author), Ji Eun Park (Author), Yeo Jung Nam (Author), Yun-jeong Shin (Author), Dong Hyun Cha (Author), Ju Tae Seo (Author), Tae Ki Yoon (Author), Sung Han Shim (Author)
• Format: Book
• Published: BMC, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Egr4 is expressed in primary and secondary spermatocytes in adult mouse testes and has a crucial role in regulating germ cell maturation. The functional loss of Egr4 blocks spermatogenesis, significantly reducing the number of spermatozoa that are produced. In this study, we exam...