Toward high-resolution modeling of small molecule-ion channel interactions

• Main Authors: Brandon J. Harris (Author), Phuong T. Nguyen (Author), Guangfeng Zhou (Author), Heike Wulff (Author), Frank DiMaio (Author), Vladimir Yarov-Yarovoy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ion channels are critical drug targets for a range of pathologies, such as epilepsy, pain, itch, autoimmunity, and cardiac arrhythmias. To develop effective and safe therapeutics, it is necessary to design small molecules with high potency and selectivity for specific ion channel subtypes. There has...