89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors

• Main Authors: Albert J. Chang (Author), Ravindra DeSilva (Author), Sandeep Jain (Author), Kimberley Lears (Author), Suzanne Lapi (Author), Buck Rogers (Author)
• Format: Book
• Published: MDPI AG, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases. Trastuzumab, an anti-HER2 monoclonal antibody, is used for the treatment of HER2 positive breast cancer and c...