89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors
The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases. Trastuzumab, an anti-HER2 monoclonal antibody, is used for the treatment of HER2 positive breast cancer and c...
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MDPI AG,
2012-01-01T00:00:00Z.
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