Consensus docking aid to model the activity of an inhibitor of DNA methyltransferase 1 inspired by de novo design

• Main Authors: Diana L. Prado-Romero (Author), Alejandro Gómez-García (Author), Raziel Cedillo-González (Author), Hassan Villegas-Quintero (Author), Juan F. Avellaneda-Tamayo (Author), Edgar López-López (Author), Fernanda I. Saldívar-González (Author), Ana L. Chávez-Hernández (Author), José L. Medina-Franco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The structure-activity relationships data available in public databases of inhibitors of DNA methyltransferases (DNMTs), families of epigenetic targets, plus the structural information of DNMT1, enables the development of a robust structure-based drug design strategy to study, at the molecular level...