The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

• Main Authors: Magdalena Kotańska (Author), Monika Kubacka (Author), Marek Bednarski (Author), Noemi Nicosia (Author), Małgorzata Szafarz (Author), Wojciech Jawień (Author), Christa E. Müller (Author), Katarzyna Kieć-Kononowicz (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GPR18 is an orphan GPCR that is activated by the cannabinoid tetrahydrocannabinol (THC). Emerging evidence indicates its involvement in the control of cardiovascular functions, including heart rate, contractility, vascular tone, as well as blood pressure. Therefore, we investigated the effects of se...