A novel approach toward the multigram synthesis of a novel Bcl2-specific inhibitor, and evaluation of its biological activity

• Main Authors: Manthra Raveendran (Author), Shivangi Sharma (Author), Sanjay Sambhajirao Palimkar (Author), M. Lakshmana Kumar (Author), H. Sahana (Author), Hassan A. Swarup (Author), Sathees C. Raghavan (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The antiapoptotic protein BCL2 is overexpressed in several cancers. It contributes to prolonged cell survival and chemoresistance, making it an excellent target for targeted cancer therapy. Over the years, several BCL2 inhibitors have been investigated extensively for their anticancer potential; how...