Liposomal Nanocarriers Designed for Sub-Endothelial Matrix Targeting under Vascular Flow Conditions

• Main Authors: Lauren B. Grimsley (Author), Phillip C. West (Author), Callie D. McAdams (Author), Charles A. Bush (Author), Stacy S. Kirkpatrick (Author), Joshua D. Arnold (Author), Michael R. Buckley (Author), Raymond A. Dieter (Author), Michael B. Freeman (Author), Michael M. McNally (Author), Scott L. Stevens (Author), Oscar H. Grandas (Author), Deidra J. H. Mountain (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular interventions result in the disruption of the tunica intima and the exposure of sub-endothelial matrix proteins. Nanoparticles designed to bind to these exposed matrices could provide targeted drug delivery systems aimed at inhibiting dysfunctional vascular remodeling and improving interven...