Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.

• Main Authors: Cristina Herrera (Author), Teresa Escalante (Author), Mathieu-Benoit Voisin (Author), Alexandra Rucavado (Author), Diego Morazán (Author), Jéssica Kele A Macêdo (Author), Juan J Calvete (Author), Libia Sanz (Author), Sussan Nourshargh (Author), José María Gutiérrez (Author), Jay W Fox (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane components in vivo, as well as by a proteomics analysis of exudates collected in tissue injected with these enzymes. Immun...