Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

• Main Authors: Huan Yang (Author), Sam J. George (Author), Dane A. Thompson (Author), Harold A. Silverman (Author), Téa Tsaava (Author), Aisling Tynan (Author), Valentin A. Pavlov (Author), Eric H. Chang (Author), Ulf Andersson (Author), Michael Brines (Author), Sangeeta S. Chavan (Author), Kevin J. Tracey (Author)
• Format: Book
• Published: BMC, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal r...