A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion

• Main Authors: Dassine Berdous (Author), Xavier Berney (Author), Ana Rodriguez Sanchez-Archidona (Author), Maxime Jan (Author), Clara Roujeau (Author), Isabel C. Lopez-Mejia (Author), Randall Mynatt (Author), Bernard Thorens (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Glucose-stimulated insulin secretion is a critical function in the regulation of glucose homeostasis, and its deregulation is associated with the development of type 2 diabetes. Here, we performed a genetic screen using islets isolated from the BXD panel of advanced recombinant inbred (R...