Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption

• Main Authors: Sophie Moulin (Author), Amandine Thomas (Author), Stefan Wagner (Author), Michael Arzt (Author), Hervé Dubouchaud (Author), Frédéric Lamarche (Author), Sophie Bouyon (Author), Guillaume Vial (Author), Diane Godin-Ribuot (Author), Jean-Louis Pépin (Author), Claire Arnaud (Author), Elise Belaidi (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: Intermittent hypoxia (IH) is one of the main features of sleep-disordered breathing (SDB). Recent findings indicate that hypoxia inducible factor-1 (HIF-1) promotes cardiomyocytes apoptosis during chronic IH, but the mechanisms involved remain to be elucidated. Here, we hypothesize that I...