Co-Delivery of an Innovative Organoselenium Compound and Paclitaxel by pH-Responsive PCL Nanoparticles to Synergistically Overcome Multidrug Resistance in Cancer

• Main Authors: Daniela Mathes (Author), Letícia Bueno Macedo (Author), Taís Baldissera Pieta (Author), Bianca Costa Maia (Author), Oscar Endrigo Dorneles Rodrigues (Author), Julliano Guerin Leal (Author), Marcelo Wendt (Author), Clarice Madalena Bueno Rolim (Author), Montserrat Mitjans (Author), Daniele Rubert Nogueira-Librelotto (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we designed the association of the organoselenium compound 5'-Seleno-(phenyl)-3'-(ferulic-amido)-thymidine (AFAT-Se), a promising innovative nucleoside analogue, with the antitumor drug paclitaxel, in poly(ε-caprolactone) (PCL)-based nanoparticles (NPs). The nanoprecipitatio...