Induction of P-glycoprotein overexpression in brain endothelial cells as a model to study blood-brain barrier efflux transport

• Main Authors: Sarah F. Hathcock (Author), Hallie E. Knight (Author), Emma G. Tong (Author), Alexandra E. Meyer (Author), Henry D. Mauser (Author), Nadine Vollmuth (Author), Brandon J. Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) is comprised of specialized brain endothelial cells (BECs) that contribute to maintaining central nervous system (CNS) homeostasis. BECs possess properties such as an array of multi-drug efflux transporters that eject various drugs and toxins, preventing their entry int...