Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

• Main Authors: Deborah A. Goldspink (Author), Van B. Lu (Author), Lawrence J. Billing (Author), Pierre Larraufie (Author), Gwen Tolhurst (Author), Fiona M. Gribble (Author), Frank Reimann (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited following activation of the Gαq-coupled free fatty acid...