Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

• मुख्य लेखकों: Deborah A. Goldspink (लेखक), Van B. Lu (लेखक), Lawrence J. Billing (लेखक), Pierre Larraufie (लेखक), Gwen Tolhurst (लेखक), Fiona M. Gribble (लेखक), Frank Reimann (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited following activation of the Gαq-coupled free fatty acid...