Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

• Váldodahkkit: Deborah A. Goldspink (Dahkki), Van B. Lu (Dahkki), Lawrence J. Billing (Dahkki), Pierre Larraufie (Dahkki), Gwen Tolhurst (Dahkki), Fiona M. Gribble (Dahkki), Frank Reimann (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2018-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited following activation of the Gαq-coupled free fatty acid...