Kanamycin and Cisplatin Ototoxicity: Differences in Patterns of Oxidative Stress, Antioxidant Enzyme Expression and Hair Cell Loss in the Cochlea

• Những tác giả chính: Alejandro Gibaja (Tác giả), Juan C. Alvarado (Tác giả), Verena Scheper (Tác giả), Liliana Carles (Tác giả), José M. Juiz (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2022-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Kanamycin and cisplatin are ototoxic drugs. The mechanisms are incompletely known. With subcutaneous kanamycin (400 mg/kg, 15 days), auditory threshold shifts were detected at days 12-13 at 16 and 32 kHz, extending to 8 and 4 kHz at days 14-15. The outer hair cell (OHC) loss was concentrated past da...