Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease

• Main Authors: Panpan Chen (Author), Zihan Zhu (Author), Haoyuan Geng (Author), Xiaoqing Cui (Author), Yuhao Han (Author), Lei Wang (Author), Yaqi Zhang (Author), Heng Lu (Author), Xiao Wang (Author), Yun Zhang (Author), Chenglong Sun (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Eclipta prostrata L. has been used in traditional medicine and known for its liver-protective properties for centuries. Wedelolactone (WEL) and demethylwedelolactone (DWEL) are the major coumarins found in E. prostrata L. However, the comprehensive characterization of these two compounds on non-alco...