TCF7 is not essential for glucose homeostasis in mice

• Main Authors: Kiran Deep Kaur (Author), Chi Kin Wong (Author), Laurie L. Baggio (Author), Jacqueline L. Beaudry (Author), Shai Fuchs (Author), Brandon L. Panaro (Author), Dianne Matthews (Author), Xiemin Cao (Author), Daniel J. Drucker (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) are incretin hormones that exert overlapping yet distinct actions on islet β-cells. We recently observed that GIP, but not GLP-1, upregulated islet expression of Transcription Factor 7 (TCF7), a gene ex...