TCF7 is not essential for glucose homeostasis in mice

• Главные авторы: Kiran Deep Kaur (Автор), Chi Kin Wong (Автор), Laurie L. Baggio (Автор), Jacqueline L. Beaudry (Автор), Shai Fuchs (Автор), Brandon L. Panaro (Автор), Dianne Matthews (Автор), Xiemin Cao (Автор), Daniel J. Drucker (Автор)
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• Опубликовано: Elsevier, 2021-06-01T00:00:00Z.
• Предметы: article
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Objective: Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) are incretin hormones that exert overlapping yet distinct actions on islet β-cells. We recently observed that GIP, but not GLP-1, upregulated islet expression of Transcription Factor 7 (TCF7), a gene ex...