TCF7 is not essential for glucose homeostasis in mice

• Egile Nagusiak: Kiran Deep Kaur (Egilea), Chi Kin Wong (Egilea), Laurie L. Baggio (Egilea), Jacqueline L. Beaudry (Egilea), Shai Fuchs (Egilea), Brandon L. Panaro (Egilea), Dianne Matthews (Egilea), Xiemin Cao (Egilea), Daniel J. Drucker (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2021-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) are incretin hormones that exert overlapping yet distinct actions on islet β-cells. We recently observed that GIP, but not GLP-1, upregulated islet expression of Transcription Factor 7 (TCF7), a gene ex...