A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy

• Main Authors: Zhao Li (Author), Tianshan She (Author), Hao Yang (Author), Tao Su (Author), Qiuxiao Shi (Author), Ze Tao (Author), Yanru Feng (Author), Fen Yang (Author), Jingqiu Cheng (Author), Xiaofeng Lu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR), which is common in colorectal cancer (CRC), induces high mortality in patients. Due to its robust and selective apoptosis induction in some CRC cells with MDR, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is attractive as a novel tool for CRC therapy. H...