Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy

• Main Authors: Lu Zhong (Author), Lu Xu (Author), Yanying Liu (Author), Qingsong Li (Author), Dongyang Zhao (Author), Zhenbao Li (Author), Huicong Zhang (Author), Haotian Zhang (Author), Qiming Kan (Author), Yongjun Wang (Author), Jin Sun (Author), Zhonggui He (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyaluronic acid (HA) is a natural ligand of tumor-targeted drug delivery systems (DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors (HARE and LYVE-1) are also overexpressing in the reticuloendothelial system (RES). Therefore, polyethylene glyco...