A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

• Main Authors: Zhiwei Zhang (Author), Shuang Fu (Author), Furun Wang (Author), Chunmiao Yang (Author), Lingchao Wang (Author), Meiyan Yang (Author), Wenpeng Zhang (Author), Wu Zhong (Author), Xiaomei Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ST-246 is an oral drug against pathogenic orthopoxvirus infections. An intravenous formulation is required for some critical patients. A ternary complex of ST-246/meglumine/hydroxypropyl-β-cyclodextrin with well-improved solubility was successfully developed in our institute. The aim of this study w...