The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

• Main Authors: Marta Poźniak (Author), Natalia Porębska (Author), Mateusz Adam Krzyścik (Author), Aleksandra Sokołowska-Wędzina (Author), Kamil Jastrzębski (Author), Martyna Sochacka (Author), Jakub Szymczyk (Author), Małgorzata Zakrzewska (Author), Jacek Otlewski (Author), Łukasz Opaliński (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs to the cancer cells using ADCs specific for tumor-associated antigens enables sparing the healthy cells and thereby redu...