Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

Small molecule kinase inhibitors (SMKIs) are widely used in oncology. Therapeutic drug monitoring (TDM) for SMKIs could reduce underexposure or overexposure. However, logistical issues such as timing of blood withdrawals hamper its implementation into clinical practice. Extrapolating a random concen...

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Main Authors: Ruben A. G. van Eerden (Author), Esther Oomen-de Hoop (Author), Aad Noordam (Author), Ron H. J. Mathijssen (Author), Stijn L. W. Koolen (Author)
Format: Book
Published: MDPI AG, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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