Feasibility of Extrapolating Randomly Taken Plasma Samples to Trough Levels for Therapeutic Drug Monitoring Purposes of Small Molecule Kinase Inhibitors

• Những tác giả chính: Ruben A. G. van Eerden (Tác giả), Esther Oomen-de Hoop (Tác giả), Aad Noordam (Tác giả), Ron H. J. Mathijssen (Tác giả), Stijn L. W. Koolen (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2021-02-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Small molecule kinase inhibitors (SMKIs) are widely used in oncology. Therapeutic drug monitoring (TDM) for SMKIs could reduce underexposure or overexposure. However, logistical issues such as timing of blood withdrawals hamper its implementation into clinical practice. Extrapolating a random concen...