No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses

• Main Authors: Martin Šíma (Author), Danica Michaličková (Author), Pavel Ryšánek (Author), Petra Cihlářová (Author), Martin Kuchař (Author), Daniela Lžičařová (Author), Jan Beroušek (Author), Jan Miroslav Hartinger (Author), Tomáš Vymazal (Author), Ondřej Slanař (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this prospective PK study was to evaluate the pharmacokinetics of ciprofloxacin dosed within the first 36 h (early phase) and after 3 days of treatment (delayed phase) using individual and population PK analysis. The secondary aim of the study was to evaluate possible dosing implications...