Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice

• Main Authors: Christina B. Leibrock (Author), Martina Feger (Author), Jakob Voelkl (Author), Ursula Kohlhofer (Author), Leticia Quintanilla-Martinez (Author), Makoto Kuro-o (Author), Florian Lang (Author)
• Formato: Libro
• Publicado: Karger Publishers, 2016-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background/Aims: Klotho is required for the inhibitory effect of FGF23 on 1,25(OH)2D3 formation and Klotho-hypomorphic mice (kl/kl) suffer from severe tissue calcification due to excessive 1,25(OH)2D3 formation with subsequent increase of Ca2+ and phosphate concentrations and stimulation of osteogen...