Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.

• Main Authors: Mariane M A Stefani (Author), Charlotte Avanzi (Author), Samira Bührer-Sékula (Author), Andrej Benjak (Author), Chloé Loiseau (Author), Pushpendra Singh (Author), Maria A A Pontes (Author), Heitor S Gonçalves (Author), Emerith M Hungria (Author), Philippe Busso (Author), Jérémie Piton (Author), Maria I S Silveira (Author), Rossilene Cruz (Author), Antônio Schetinni (Author), Maurício B Costa (Author), Marcos C L Virmond (Author), Suzana M Diorio (Author), Ida M F Dias-Baptista (Author), Patricia S Rosa (Author), Masanori Matsuoka (Author), Maria L F Penna (Author), Stewart T Cole (Author), Gerson O Penna (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolutio...