Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics

• المؤلفون الرئيسيون: Michel Siegel (مؤلف), Guido Steiner (مؤلف), Linnea C. Franssen (مؤلف), Francesca Carratu (مؤلف), James Herron (مؤلف), Katharina Hartman (مؤلف), Cary M. Looney (مؤلف), Axel Ducret (مؤلف), Katharine Bray-French (مؤلف), Olivier Rohr (مؤلف), Timothy P. Hickling (مؤلف), Noel Smith (مؤلف), Céline Marban-Doran (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Immunogenicity, defined as the ability to provoke an immune response, can be either wanted (i.e., vaccines) or unwanted. The latter refers to an immune response to protein or peptide therapeutics, characterized by the production of anti-drug antibodies, which may affect the efficacy and/or the safet...