Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics

• Main Authors: Michel Siegel (Author), Guido Steiner (Author), Linnea C. Franssen (Author), Francesca Carratu (Author), James Herron (Author), Katharina Hartman (Author), Cary M. Looney (Author), Axel Ducret (Author), Katharine Bray-French (Author), Olivier Rohr (Author), Timothy P. Hickling (Author), Noel Smith (Author), Céline Marban-Doran (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunogenicity, defined as the ability to provoke an immune response, can be either wanted (i.e., vaccines) or unwanted. The latter refers to an immune response to protein or peptide therapeutics, characterized by the production of anti-drug antibodies, which may affect the efficacy and/or the safet...