Metabolism of IMM-H004 and Its Pharmacokinetic-Pharmacodynamic Analysis in Cerebral Ischemia/Reperfusion Injured Rats

• Main Authors: Ziqian Zhang (Author), Dandan Liu (Author), Jianwei Jiang (Author), Xiuyun Song (Author), Xiaowen Zou (Author), Shifeng Chu (Author), Kebo Xie (Author), Jungui Dai (Author), Naihong Chen (Author), Li Sheng (Author), Yan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IMM-H004, a derivative of coumarin, is a promising candidate for the treatment of cerebral ischemia. The pharmacodynamic mechanisms of IMM-H004 are still under exploration. The present study was conducted to explore the pharmacoactive substances of IMM-H004 from the perspective of drug metabolism. F...