P2X7 Receptor Agonist 2'(3')-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington's Disease

• Autori principali: Alberto Martire (Autore), Rita Pepponi (Autore), Francesco Liguori (Autore), Cinzia Volonté (Autore), Patrizia Popoli (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Huntington's disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the pathogenesis of the disease; accordingly, the...