Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist

• Main Authors: Jia Deng (Author), Yuta Fukushima (Author), Kosuke Nozaki (Author), Hideyuki Nakanishi (Author), Erica Yada (Author), Yuki Terai (Author), Kenji Fueki (Author), Keiji Itaka (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Messenger RNA (mRNA) is an emerging drug modality for protein replacement therapy. As mRNA efficiently provides protein expression in post-mitotic cells without the risk of insertional mutagenesis, direct delivery of mRNA can be applied, not only as an alternative to gene therapy, but also for vario...