Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

• Main Authors: Gui-Cun Yang (Author), You-Hua Xu (Author), Hong-Xia Chen (Author), Xiao-Jing Wang (Author)
• Format: Knjiga
• Izdano: Hindawi Limited, 2015-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The disruption of normal hematopoiesis has been observed in leukemia, but the mechanism is unclear. Osteoblasts originate from bone mesenchymal stem cells (BMSCs) and can maintain normal hematopoiesis. To investigate how leukemic cells inhibit the osteogenic differentiation of BMSCs and the role of...