Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

• Những tác giả chính: Gui-Cun Yang (Tác giả), You-Hua Xu (Tác giả), Hong-Xia Chen (Tác giả), Xiao-Jing Wang (Tác giả)
• Định dạng: Sách
• Được phát hành: Hindawi Limited, 2015-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The disruption of normal hematopoiesis has been observed in leukemia, but the mechanism is unclear. Osteoblasts originate from bone mesenchymal stem cells (BMSCs) and can maintain normal hematopoiesis. To investigate how leukemic cells inhibit the osteogenic differentiation of BMSCs and the role of...