Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

• Main Authors: Vincent Runtuwene (Author), Mark van Eekelen (Author), John Overvoorde (Author), Holger Rehmann (Author), Helger G. Yntema (Author), Willy M. Nillesen (Author), Arie van Haeringen (Author), Ineke van der Burgt (Author), Boudewijn Burgering (Author), Jeroen den Hertog (Author)
• Format: Book
• Published: The Company of Biologists, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated with dysregulation of the Ras-mitogen-activated-protein-kinase (MAPK) signaling pathway. Recently, two mutations in...