Acidic Oligosaccharide Sugar Chain, a Marine-Derived Acidic Oligosaccharide, Inhibits the Cytotoxicity and Aggregation of Amyloid Beta Protein

• Main Authors: Jinfeng Hu (Author), Meiyu Geng (Author), Jing Li (Author), Xianliang Xin (Author), Jia Wang (Author), Minke Tang (Author), Juntian Zhang (Author), Xiao Zhang (Author), Jian Ding (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Aβ). We observed that AOSC inhibited the toxicity induced by Aβ in both primarily cortical cells and the SH-SY5Y cell line. We also...