Effect of an alkyl spacer on the morphology and internalization of MUC1 aptamer‐naphthalimide amphiphiles for targeting and imaging triple negative breast cancer cells

• Main Authors: Huihui Kuang (Author), Zachary Schneiderman (Author), Ahmed M. Shabana (Author), Gabriella C. Russo (Author), Jun Guo (Author), Denis Wirtz (Author), Efrosini Kokkoli (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Despite decades of research, there are few targeted treatment options available for triple negative breast cancer (TNBC), leaving chemotherapy, and radiation treatment regimes with poor response and high toxicity. Herein aptamer‐amphiphiles were synthesized which selectively bind to the muc...