Computer-assisted discovery of safe and effective DprE1/ aaRSs Inhibitors against TB utilizing Drug Repurposing approach

• Autori principali: Mohd. Imran (Autore), Abida (Autore), Nawaf M. Alotaibi (Autore), Hamdy Khamees Thabet (Autore), Jamal Alhameedi Alruwaili (Autore), Syed Mohammed Basheeruddin Asdaq (Autore), Lina Eltaib (Autore), Mehnaz Kamal (Autore), Amal Bader Hommod Alshammari (Autore), Abdulmajeed Mohammed Abdullah Alshammari (Autore), Ahmed Alshehri (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: The emergence of various drug-resistant strains of Mycobacterium tuberculosis compelled medicinal chemists to expedite the discovery of novel, safer alternatives to present regimens. Decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1), an essential component of arabinogalactan bios...