Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights

• Автори: Abdelrahman Hamdi (Автор), Muhammad Yaseen (Автор), Wafaa A. Ewes (Автор), Mashooq Ahmad Bhat (Автор), Noha I. Ziedan (Автор), Hamed W. El-Shafey (Автор), Ahmed A. B. Mohamed (Автор), Mohamed R. Elnagar (Автор), Abdullah Haikal (Автор), Dina I. A. Othman (Автор), Abdullah A. Elgazar (Автор), Ahmed H. A. Abusabaa (Автор), Kamal S. Abdelrahman (Автор), Osama M. Soltan (Автор), Mostafa M. Elbadawi (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis of 17 new derivatives of 2,4-TZDs hybrids was feasible by incorporating two known bioactive scaffolds, benzothiazole hete...