Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

• Main Authors: Pere Fontova (Author), Helena Colom (Author), Raül Rigo-Bonnin (Author), Lisanne N. van Merendonk (Author), Anna Vidal-Alabró (Author), Nuria Montero (Author), Edoardo Melilli (Author), Maria Meneghini (Author), Anna Manonelles (Author), Josep M. Cruzado (Author), Juan Torras (Author), Josep Maria Grinyó (Author), Oriol Bestard (Author), Nuria Lloberas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient pharmacokinetic variability leading to frequent over- and under-immunosuppression. While routine therapeutic drug monitoring (T...