Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

• Main Authors: Rachel L. Berry (Author), Derya D. Ozdemir (Author), Bruce Aronow (Author), Nils O. Lindström (Author), Tatiana Dudnakova (Author), Anna Thornburn (Author), Paul Perry (Author), Richard Baldock (Author), Chris Armit (Author), Anagha Joshi (Author), Cécile Jeanpierre (Author), Jingdong Shan (Author), Seppo Vainio (Author), James Baily (Author), David Brownstein (Author), Jamie Davies (Author), Nicholas D. Hastie (Author), Peter Hohenstein (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a develop...