Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

• Main Authors: Jiahong Xiang (Author), Mengqi Wu (Author), Jianchao Wang (Author), Mengmeng Lin (Author), Mengmeng Sun (Author), Xin Li (Author), Ruijuan Xing (Author), Ran Guo (Author), Jianmin Gu (Author), Tao Lyu (Author), Lei Wang (Author), Xiaowei Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC50 0.078 nM), and thus has antitumor drug development prospects. However, its pharmacokinetics and plasma protein binding properties rem...