Characterization of Alpelisib in Rat Plasma by a Newly Developed UPLC-MS/MS Method: Application to a Drug-Drug Interaction Study

• Main Authors: Qiong Wang (Author), Xia Lan (Author), Zhuofei Zhao (Author), Xiaohang Su (Author), Yuji Zhang (Author), Xiao-Yang Zhou (Author), Ren-Ai Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alpelisib, an oral selective and small-molecule phosphoinositide 3-kinase inhibitor, was lately approved in the United States to treat breast cancer. A sensitive method to quantify alpelisib levels in rat plasma on the basis of ultra-performance liquid chromatography-tandem mass spectrometry techniq...