Chronic helminth infection does not exacerbate Mycobacterium tuberculosis infection.

• Main Authors: Marc P Hübner (Author), Kristin E Killoran (Author), Michael Rajnik (Author), Samuel Wilson (Author), Kevin C Yim (Author), Marina N Torrero (Author), Christopher P Morris (Author), Boris Nikonenko (Author), Jorge C G Blanco (Author), Val G Hemming (Author), Edward Mitre (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is necessary for control of Mycobacterium tuberculosis (MTB) infection, we hypothesized that chronic helminth infections may exacerbate the cour...