Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca²⁺ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties

• Main Authors: Irene Pachón-Angona (Author), Paul J. Bernard (Author), Alexey Simakov (Author), Maciej Maj (Author), Krzysztof Jozwiak (Author), Anna Novotna (Author), Carina Lemke (Author), Michael Gütschow (Author), Helene Martin (Author), María-Jesú (Author), José-Marco Contelles (Author), Lhassane Ismaili (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds <b>4a</b>-<b>l</b>, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxidant capacity, c...