Augmenting external control arms using Bayesian borrowing: a case study in first-line non-small cell lung cancer

• Main Authors: Alessandria Struebing (Author), Chelsea McKibbon (Author), Haoyao Ruan (Author), Emma Mackay (Author), Natalie Dennis (Author), Russanthy Velummailum (Author), Philip He (Author), Yoko Tanaka (Author), Yan Xiong (Author), Aaron Springford (Author), Mats Rosenlund (Author)
• Format: Book
• Published: Becaris Publishing Limited, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: This study aimed to improve comparative effectiveness estimates and discuss challenges encountered through the application of Bayesian borrowing (BB) methods to augment an external control arm (ECA) constructed from real-world data (RWD) using historical clinical trial data in first-line non-sm...