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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O<sub>2</sub>) is a life-saving intervention for patients experiencing respiratory distress. However, prolonged exposure to hyperoxia can compromise bacterial clearance processes, due to oxid...

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Main Authors: Alex G. Gauthier (Author), Jiaqi Wu (Author), Mosi Lin (Author), Ravikumar Sitapara (Author), Abhijit Kulkarni (Author), Ganesh A. Thakur (Author), Edward E. Schmidt (Author), Jeanette C. Perron (Author), Charles R. Ashby (Author), Lin L. Mantell (Author)
Format: Book
Published: MDPI AG, 2021-01-01T00:00:00Z.
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