FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer's disease through the ubiquitination-dependent degradation of amyloid precursor protein

• Main Authors: Liqun Qu (Author), Yong Tang (Author), Jianhui Wu (Author), Xiaoyun Yun (Author), Hang Hong Lo (Author), Linlin Song (Author), Xingxia Wang (Author), Huimiao Wang (Author), Ruilong Zhang (Author), Menghan Liu (Author), Cairen Wang (Author), Jerome P. L. Ng (Author), Xianjun Fu (Author), Io Nam Wong (Author), Vincent Kam Wai Wong (Author), Betty Yuen Kwan Law (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activating the ubiquitin-proteasome system to dismantle disease- related proteins such as tau, β-amyloid, APP, and α-synuclein is an important focus in the research of neurodegenerative proteinopathy. By analyzing the serum RNA extracted from wild-type and Alzheimer's diseas...