Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1

• Main Authors: Ziming Yang (Author), Li Zhang (Author), Jinglei Liu (Author), Fenglai Lu (Author), Lei Wang (Author), Yueyuan Chen (Author), Dianpeng Li (Author)
• Format: Bog
• Udgivet: BMC, 2019-06-01T00:00:00Z.
• Fag: article
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Abstract Background Tomato fruit (Lycopersicon esculentum Mill.) has been suggested to be useful for the prevention of diabetes. Esculeoside A is the main saponin compounds in tomatoes. This study investigated the hypoglycemic effects and the underlying mechanism of esculeoside A in C57BLKS/Leprdb (...